- Status Indicator
- Dual Wall Frame

- More Power: With a more powerful architecture that’s engineered to power advanced technology and future applications, the ZD421 can run more tasks, perform more operations simultaneously and maintain security
- More Intuitive User Interface: The ZD421 has a premium and more intuitive user interface for more control and ease of use. The three-button user interface with five LED icons makes it simple to see what’s needed to keep the printer operational.
- More Connectivity: With more standard connectivity options, including USB, USB Host, Serial, Ethernet and dual wireless with 802.11ac Wi-Fi and Bluetooth 4.1, the ZD421 is easy to connect and manage on your network or standalone.
- More Application Flexibility: The ZD421 is available in a variety of models including healthcare, with disinfectant-ready plastics and sealed button interface, and a thermal transfer model with a groundbreaking ribbon cartridge that makes it easier than ever to load ribbon for more applications.
- More Software Tools: Print DNA software suite makes it easy to get your ZD421 up and running quickly and securely. And with Zebra’s Printer Profile Manager Enterprise, you can manage, secure and troubleshoot your networked printers from one remote location.
You need a reliable printer that delivers quality performance, now and for years to come. It needs to offer key features, and be easy to setup, operate, manage and maintain – onsite or remotely. It needs to be secure, whether it is integrated onto your network or not, to prevent downtime and costly cyberattacks. You need it. Zebra delivers it, for more than 50 years. We design our printers to match your workflows, ensuring they are hassle-free and ready to work. Day in and day out. We’re always innovating to deliver the best to help you advance your business and be ready for what’s next. Building on the legacy of Zebra’s popular GK Series, ZD421 printers add even more capabilities and security measures to set you up for years of use.
Migrate from G to Z
The ZD421 builds on the legacy of Zebra’s GK Series printers, offering you the functions and capabilities of its predecessor – and much more. The next-generation ZD421 leverages this heritage to deliver advanced features for a new era of intelligence and forward flexibility.
Intuitive and Powerful Operation
The ZD421 offers new, advanced features that make it stand apart. It includes a new, more intuitive user interface, powerful architecture and field-upgradeable wireless kit. It also has new media guide and media handling designs that make daily operation even easier.
Multiple Models to Match Your Needs
Available in direct thermal, thermal transfer, and ribbon cartridge models, the ZD421 meets a wide variety of application requirements.
Get Years of Printing Performance
The ZD421 is designed to handle advancing technology. Featuring an innovative architecture, it’s engineered to power future printing. In comparison, it’s 30% more powerful than the ZD420 Series and 700% more than the GK Series. This lets you run more tasks, perform more operations simultaneously, maintain security and be ready for what’s next.
Backwards Compatible with Virtually Any Existing Printer
Deploy your ZD421 into your existing printer fleet with confidence. Use the same label formats and applications you’re using today. It supports both EPL and ZPL printer languages, and can emulate languages normally associated with other printer brands using Zebra’s Print DNA tool, Virtual Devices.
Connect it Your Way
Integrate your ZD421 onto your existing wired and wireless networks, or connect it directly to any PC. Every ZD421 comes standard with USB and USB Host, and offers optional Ethernet, Serial and dual wireless radio with fast 802.11ac Wi-Fi™ and Bluetooth® 4.1. Print from any Windows®, Android™ or iOS® device. Get your ZD421 up and running with Zebra’s printer setup mobile app using Bluetooth Low Energy (BLE). Use the included Print Touch tag (NFC) to simply tap to pair and print.
Operate with Ease and See Status At-A-Glance
Take the guesswork out of printer status with the ZD421’s five LED icons to instantly see what’s needed to keep your printers up and running, from replenishing media to resolving printer issues. The advanced three-button user interface replaces the typical single-button/single-light interface common in desktop printers to offer added functionality and control. And, color-coded touch points guide you through media-handling tasks for speedy media changes.
Groundbreaking Cartridge for Instant Ribbon Changes
The ZD421 is the only thermal printer to offer a ribbon cartridge that takes just a few seconds to load with fool-proof, one-way, first-time and every-time instant loading. The smart chip in the ribbon lets you know when the ribbon needs replacing.
Turn Your ZD421 Into a Portable Printer
Easily transport your ZD421 printer on a cart or with Zebra’s optional carrying case, using the battery option. Print on the spot to reduce steps and increase productivity. Power through a full shift with the high-capacity battery.
Movable Sensor for Comprehensive Media Compatibility
The ZD421’s movable media sensor lets you use virtually any media for greater flexibility across a variety of use cases.
Print Securely and Confidently, Without Hassles
Print DNA suite of software, powered by our Link-OS operating system, will get your printer up and running quickly and securely. Print consistently, and uninterrupted with a solution that’s fully integrated and interoperable, and will enable your printer to evolve with your business needs.
Update, Troubleshoot and Monitor – All From a Single Location
With Zebra’s Printer Profile Manager Enterprise, part of Print DNA, you have the ability to easily manage, secure and troubleshoot your networked printers from one remote location. Manage one printer, a group of specific printers or all printers anywhere in the world.
Unparalleled, Peace-of-Mind Printer Security
Shield yourself from cyberattacks with Zebra’s PrintSecure, part of Print DNA. Easily configure your printers via secure connections, identify vulnerabilities, block unauthorized access and more.
Zebra’s Thermal Printers with Print DNA Make MPS Easy
Looking to gain control and visibility of your printer fleets with MPS? With the Print DNA software toolset, your Zebra MPS provider can remotely manage and optimize your printers, track and automate supplies replenishment and ensure security.
Zebra Certified Supplies
Printing supplies provide a digital voice for assets across your supply chain. You rely on them to disseminate critical data throughout your organization. If something goes wrong with your printing supplies, operations are interrupted, productivity suffers and costs rise. That’s why we design, produce and rigorously pretest our own line of labels, tags and receipt paper to ensure consistent, optimized performance in your Zebra printer. For industry-leading quality, service and expertise, choose Zebra Certified Supplies.
Backed by Zebra’s Worldwide Service and Support
Access repair support services anywhere around the globe through Zebra and its trusted network of more than 10,000 partners. Zebra OneCareâ„¢ provides enhanced coverage that exceeds standard warranty.
Application Flexibility
• Manufacturing: work in progress, product ID/serial numbers, labels, agency labels, warning labels • Transportation & Logistics: order picking/packing, shipping, receiving, cross-docking, asset tracking, compliance labeling • Retail: price labeling, markdowns, shelf labeling, return labeling, food information labeling, product labeling, inventory and asset labeling • Healthcare: patient identification, pharmacy labeling, specimen identification, laboratory specimen labeling
Markets and Applications
Retail • Shelf labels • Price markdowns • Return tags • Asset and inventory labels • Food information labels • Receipts • Pharmacy labels Healthcare • Lab and specimen labels • Prescription labels • Patient ID wristbands • Blood and IV bag labels • Patient record labels • Asset labels Transportation & Logistics • Shipping and receiving labels • Packing slips • Asset labels Light Manufacturing • Agency labels • Product labels • Apparel tags • Work-in-Process (WIP) • Inventory labels • Shipping labels Government • Asset labels • Record labels Services/Hospitality • Service reminder labels • Ticketing
Elevate your expectations: the advanced desktop printer that delivers the features, flexibility, reliability and security you need
You need a reliable printer that delivers quality performance, now and for years to come. It needs to offer key features, and be easy to setup, operate, manage and maintain - onsite or remotely. It needs to be secure, whether it is integrated onto your network or not, to prevent downtime and costly cyberattacks. You need it. Zebra delivers it, for more than 50 years. We design our printers to match your workflows, ensuring they are hassle-free and ready to work. Day in and day out. We're always innovating to deliver the best to help you advance your business and be ready for what's next. Building on the legacy of Zebra's popular GK Series, ZD421 printers add even more capabilities and security measures to set you up for years of use.
Simple to Use
Intuitive and Powerful Operation
The ZD421 offers new, advanced features that make it stand apart. It includes a new, more intuitive user interface, powerful architecture and field-upgradeable wireless kit. It also has new media guide and media handling designs that make daily operation even easier.
Flexible to Support Nearly Every Use Case
Multiple Models to Match Your Needs
Available in direct thermal, thermal transfer, healthcare and ribbon cartridge models, the ZD421 meets a wide variety of application requirements.
Ready for Now and What's Next
Get Years of Printing Performance
The ZD421 is designed to handle advancing technology. Featuring an innovative architecture, it's engineered to power future printing. In comparison, it's 30% more powerful than the ZD420 Series and 700% more than the GK Series. This lets you run more tasks, perform more operations simultaneously, maintain security and be ready for what's next.
It's Time to Advance
Migrate from G to Z
The ZD421 builds on the legacy of Zebra's GK Series printers, offering you the functions and capabilities of its predecessor - and much more. The next-generation ZD421 leverages this heritage to deliver advanced features for a new era of intelligence and forward flexibility.
- Label
- Receipt
- Roll Fed
- Fanfold
- Die-cut Label
- Continuous Label
- Black Mark
- Tag Stock
- Continuous Paper
- Wristband
- Gap
- ZPL
- EPL
- ZPL II
- EPL II
- XML
- ZBI
- EZPL
- ZD421c Thermal Transfer Printer
- Empty Ribbon Take-up Cores
- Ribbon Core Adapters
- AC Power Supply
- Power Cord
- USB Cable
- Quick Start Guide
- Regulatory Guide
- AC
- USB
- iOS
- Android
- PC
Printer Expert!