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Zebra ZD421-HC Barcode Label Printer

Elevate your expectations with Zebra's advanced healthcare desktop printers. Zebra ZD421-HC - Elevate your expectations with Zebra's advanced ZD421-HC 4-inch Desktop Printers. Building on the legacy of Zebra's GK Series and ZD420 healthcare printers, the ZD421-HC delivers the flexibility and reliability you need, with even more capabilities and security, to set you up for years of use. The ZD421-HC is easy to clean, sanitize and safely power. Made with disinfectant-ready plastics, UV-resistant housing and a sealed button interface that makes the ZD421-HC help prevent the spread of infections in hospitals and clinics. The ZD421-HC features a new, more intuitive user interface, powerful architecture and field-upgradeable wireless kit. Available in direct thermal, thermal transfer and ribbon cartridge models, all specifically for healthcare, the ZD421-HC printer meets a wide variety of healthcare-specific use cases and requirements.
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$662.47
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Zebra ZD421-HC Barcode Label Printer Model Overview
The ZD421-HC  advanced desktop printer is built specifically for healthcare environments, including disinfectant-ready white plastics, UV-resistant housing with sealed button interface, and an IEC 60601-1 compliant power supply.

Key Features:
  • Replaces the legacy GK Series and ZD420 Series, offering more functions and capabilities powered by a new innovative architecture that can run more tasks, perform more operations simultaneously and is ready for what's next.
  • Operates with ease with the five LED icons to take the guesswork out of printer status, and has a three-button user interface for added functionality and control.
  • Connectivity includes USB and USB Host standard, and optional Ethernet, Serial and dual wireless radio with 802.11ac Wi-Fi and Bluetooth 4.1 - all available as field-upgradeable options.
  • Zebra's exclusive Print DNA software suite makes it easy to get printers up and running quickly. And PrintSecure makes it easy to shield printers from cyberattacks.
  • Increase printer flexibility and use cases with options and accessories, including 300 dpi, desktop battery and carrying case, peeler, cutter, keyboard display unit, mounting plate, and enclosed power supply.


You need a reliable printer built for healthcare that delivers quality performance, now and for years to come. It needs key features, and be easy to setup, operate, manage and maintain—onsite or remotely. It needs to be secure to protect patient information, whether integrated onto your network or not, to prevent downtime and costly cyberattacks. You need it, and Zebra delivers it, for more than 50 years. We’ve engineered our healthcare printers to match your workflows for hassle-free performance. Building on the legacy of Zebra’s GK Series and ZD420 healthcare printers, the ZD421 delivers the flexibility and reliability you need, with even more capabilities and security, to set you up for years of use.


Migrate from G to Z 

The ZD421 builds on the legacy of Zebra’s GK Series and ZD420 Series printers, offering you the functions and capabilities of its predecessor—and much more. The next-generation ZD421 leverages this heritage to deliver advanced features for a new era of intelligence and forward flexibility, packaged in a ready-to-work healthcare model.


Easy to Clean, Sanitize and Safely Power 

Disinfectant-ready plastics, UV-resistant housing and a sealed button interface make the ZD421 healthcare printer easy to clean and sanitize, helping prevent the spread of infections in hospitals and clinics. And, the power supply is IEC 60601-1 compliant for use in healthcare facilities.


Intuitive and Powerful Operation 

The ZD421 offers new, advanced features that make it stand apart. It includes a new, more intuitive user interface, powerful architecture and field-upgradeable wireless kit. It also has new media guide and media handling designs that make daily operation even easier.


Multiple Models to Match Your Needs 

Available in direct thermal, thermal transfer and ribbon cartridge models, all specifically for healthcare, the ZD421 healthcare printer meets a wide variety of healthcare-specific use cases and requirements.


Get Years of Printing Performance 

Featuring an innovative architecture, the ZD421 is engineered to power future printing. It’s 30% more powerful than the ZD420 Series and 700% more than the GK Series. Perform more operations simultaneously, maintain security and be ready for what’s next.


Backwards Compatible with Virtually Any Existing Thermal Printer 

Integrate your ZD421 into your existing printer fleets with confidence. Use the same label formats and applications you’re using today. It supports both EPL and ZPL printer languages, and can emulate languages normally associated with other printer brands using Zebra’s Print DNA tool, Virtual Devices.


Connect it Your Way 

Integrate your ZD421 onto your existing wired and wireless networks, or connect it directly to any PC. Every ZD421 comes standard with USB and USB Host, and offers optional Ethernet, Serial and dual wireless radio with fast 802.11ac Wi-Fi™ and Bluetooth® 4.1. Print from any Windows®, Android™ or iOS® device. Get your ZD421 up and running with Zebra’s printer setup mobile app using Bluetooth Low Energy (BLE). Use the included Print Touch tag (NFC) to simply tap to pair and print.


Operate with Ease and See Status At-A-Glance 

The ZD421’s five LED icons allow you to instantly see what’s needed to keep your printers up and running, from replenishing media to resolving printer issues. The advanced three-button user interface replaces the typical single-button/single-light interface common in desktop printers. And, color-coded touch points guide you through media-handling tasks for speedy media changes.


Groundbreaking Cartridge for Instant Ribbon Changes 

The ZD421 is the only thermal printer to offer a ribbon cartridge that takes just a few seconds to load with fool-proof, one-way, first-time and every-time instant loading. The smart chip in the ribbon lets you know when the ribbon needs replacing.


Turn Your ZD421 Into a Portable Printer 

Easily transport your ZD421 printer on a cart or with Zebra’s optional carrying case1 , using the battery option. Print on the spot to reduce steps and increase productivity. Power through a full shift with the high-capacity battery.


Movable Sensor for Comprehensive Media Compatibility 

The ZD421 movable media sensor lets you use virtually any media for greater flexibility across a variety of use cases.


Print Securely and Confidently, Without Hassles 

Print DNA suite of software, powered by our Link-OS® operating system, will get your printer up and running quickly and securely. Print consistently, and uninterrupted with a solution that’s fully integrated and interoperable, and will enable your printer to evolve with your business needs.


Update, Troubleshoot and Monitor–All From a Single Location 

With Zebra’s Printer Profile Manager Enterprise, part of Print DNA, you have the ability to easily manage, secure and troubleshoot your networked printers from one remote location anywhere in the world.


Unparalleled, Peace-of-Mind Printer Security 

Shield yourself from cyberattacks with Zebra’s PrintSecure, part of Print DNA. Easily configure your printers via secure connections, identify vulnerabilities, block unauthorized access and more.


Zebra’s Thermal Printers with Print DNA 

Make MPS Easy Looking to gain control and visibility of your printer fleets with MPS? With the Print DNA software suite, your Zebra MPS provider can remotely manage and optimize your printers, track and automate supplies replenishment and ensure security


Zebra Certified Supplies 

Printing supplies provide a digital voice for assets across your supply chain. You rely on them to disseminate critical data throughout your organization. That’s why we design, produce and rigorously pretest our own line of labels, tags and receipt paper to ensure consistent, optimized performance in your Zebra printer. For industry-leading quality, service and expertise, choose Zebra Certified Supplies.


Backed by Zebra’s Worldwide Service and Support 

Access repair support services anywhere around the globe through Zebra and its trusted network of more than 10,000 partners. Zebra OneCare™ provides enhanced coverage that exceeds standard warranty.


Healthcare Features 

• Healthcare preferred white color scheme • Healthcare-compliant power supply, IEC 60601-1 certified • Disinfectant-ready, easy-to-clean plastics with sealed button interface • UV-resistant housing supports UV cleaning protocols Standard Features • Print methods: Thermal Transfer or Direct Thermal • ZPL and EPL programming languages • 5 status icon, 3 button user interface • USB 2.0, USB Host • Printer setup mobile app for Android and iOS via BLE (Bluetooth Low Energy 5) connection* * BLE is intended for use with Zebra printer setup mobile app only • Real Time Clock (RTC) • OpenACCESS™ for easy media loading • Dual-wall frame construction • ENERGY STAR® certified


Markets and Applications 

Healthcare • Prescription labels • Lab and specimen labels • Patient ID wristbands • Blood and IV bag labels • Patient record labels • Asset labels