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Zebra ZD621-HC Barcode Label Printer

Premium features, maximum performance and unmatched security for years of quality printing in healthcare environments. Zebra ZD621-HC - Zebra's ZD621-HC 4-Inch Desktop Printers provide premium features, maximum performance and unmatched security for years of quality printing in healthcare environments. The ZD621-HC printers are made with healthcare-specific engineering with disinfectant-ready plastics, UV-resistant and medical-grade power supply. The ZD621-HD has a new standard 4.3-inch, full color LCD touch display with intuitive menu. From industry-leading print speeds to portability for application flexibility to emerging technology to field-installable options, the ZD621-HC stands apart. Available in direct thermal and thermal transfer healthcare models, and a RFID model, the ZD621-HC supports a wide variety of healthcare-specific use cases and requirements.
Full specifications (PDF)
Starting at:
$740.96
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Zebra ZD621-HC Barcode Label Printer Model Overview
The ZD621-HC premium desktop printer is built specifically for healthcare environments, with disinfectant-ready white plastics, UV-resistant housing with sealed button interface, IEC 60601-1 compliant power supply, and a full color touch LCD.

Key Features:
  • Replaces the legacy GX Series, ZD500 and ZD620 Series, offering more functions and capabilities powered by a new innovative architecture that can run more tasks, perform more operations simultaneously and is ready for what's next.
  • Operates with ease with the five LED icons to take the guesswork out of printer status, and has a three-button user interface for added functionality and control. Get the optional 4.3" full color touch LCD with 3-button user interface.
  • Connectivity includes Ethernet, Serial, USB and USB Host standard, and optional dual wireless radio with 802.11ac Wi-Fi and Bluetooth 4.1 - available as factory- or field-installable.
  • Zebra's exclusive Print DNA software suite makes it easy to get printers up and running quickly. And PrintSecure makes it easy to shield printers from cyberattacks.
  • Increase printer flexibility and use cases with options and accessories, including 300 dpi, desktop battery, carrying case, peeler, cutter, keyboard display unit, mounting plate, and enclosed power supply.


You need a premium, quality healthcare printer that’s built to perform flawlessly—day in and day out. Rely on Zebra’s ZD621 healthcare desktop printers, built specifically for healthcare, and advancing the proven and popular ZD620 printers. Don’t compromise. Get it all: an innovative new architecture to power our ever-expanding printer capabilities and software. Healthcare-specific engineering with disinfectant-ready plastics, UV-resistant and medical-grade power supply. Unmatched security that’s constantly evolving to shield you from cyberattacks and safeguard your sensitive data, including patient information. A new standard 4.3 in., full-color LCD touch display with intuitive menu. Enhanced features, communication and field-installable media-handling options. And, increased remote management capabilities. Together, these give you outstanding print performance, years of optimal use, industry-leading reliability and unparalleled intelligence and security to keep you moving forward.


Extending the ZD-Series Legacy

Zebra’s ZD620 Series printers are known for quality, premium performance. As you select your next printer, you can be confident the next-generation ZD621 includes everything you loved in those legacy printers, and builds on this heritage to deliver best-in-class features for this new era of intelligence and forward adaptability.


Easy to Clean, Sanitize and Safely Power

Disinfectant-ready plastics, UV-resistant housing and a sealed button interface make the ZD621 healthcare printers easy to clean and sanitize, helping prevent the spread of infections in hospitals and clinics. And, the power supply is IEC 60601-1 compliant for use in healthcare facilities.


Premier Printing Performance

Rely on the ZD621 to help you power through—day after day. From industry-leading print speeds to portability for application flexibility to emerging technology to field-installable options, the ZD621 stands apart. Available in direct thermal and thermal transfer healthcare models, and a RFID model1 , the ZD621 supports a wide variety of healthcare-specific use cases and requirements.


Simple to Deploy, Use, Manage and Secure

Backed by Zebra’s innovative Print DNA™ software suite, the ZD621 is incredibly simple to operate. Deploy it anywhere with setup tools, wizards and emulation capabilities. The large, touch LED display and intuitive user interface make operation easy with minimal training. See status at a glance with the five LED icons. Take advantage of robust remote management capabilities that alleviate IT burdens. And, built-in security hardens your infrastructure from cyberattacks.


Designed to Perform Today and Tomorrow

Technology is constantly advancing. So can your ZD621 printer. Featuring an innovative architecture, it’s engineered to power future printing. In comparison, it’s 30% more powerful than the ZD620 Series. This gives you the ability to run more tasks, perform more operations simultaneously, maintain security and be ready for what’s next.


Intuitive User Interface

Interact at a touch with the 4.3 in., full-color LCD touch display, standard on the ZD621 healthcare and RFID models. The easy-touch menu features step-by-step setup wizards, troubleshooting animations, media-loading and calibration guidance and supports stand-alone printing applications. Zebra touchscreens are expertly designed and tested for toughness and reliability consistent with Zebra’s printer portfolio, including robust tolerance to temperature, humidity, dust and other environmental challenges.


Connect Your Way with Comprehensive Communication

Integrate your ZD621 onto your existing wired and wireless networks or connect it directly to any PC. Every ZD621 comes with Ethernet, USB 2.0 and USB Host, or add an optional dual wireless radio with fast 802.11ac Wi-Fi™ and Bluetooth® 4.1. Print from any Windows®, Android™ or iOS® device, and integrate your ZD621 with Zebra’s printer setup mobile app using Bluetooth Low Energy (BLE). And with the included Print Touch tag (NFC), you can simply tap a compatible mobile device on the ZD621 to pair and print—as well as instantly access Zebra’s extensive knowledge base of how-to videos.


Turn Your ZD621 Into a Portable Printer

Easily transport your ZD621 healthcare printer on a cart or with Zebra’s optional carrying case, using the battery option. Print on the-spot to reduce steps, increase productivity, and improve task accuracy. Power through a full shift with the high-capacity battery.


Movable Sensor for Comprehensive Media Compatibility

The ZD621 movable media sensor lets you use virtually any media for greater flexibility across a variety of use cases.


Print Securely and Confidently, Without Hassles

Print DNA suite of software, powered by our Link-OS® operating system, will get your printer up and running quickly and securely. Print consistently, and uninterrupted with a solution that’s fully integrated and interoperable, and will enable your printer to evolve with your business needs


Update, Troubleshoot and Monitor–All From a Single Location

With Zebra’s Printer Profile Manager Enterprise, part of Print DNA, you have the ability to easily manage, secure and troubleshoot your networked printers from one remote location. Manage one printer, a group of specific printers or all printers anywhere in the world.


Unparalleled, Peace-of-Mind Printer Security

Shield yourself from cyberattacks with Zebra’s PrintSecure, part of Print DNA. Easily configure your printers via secure connections, identify vulnerabilities, block unauthorized access and more.


Zebra’s Thermal Printers with Print DNA Make MPS Easy

Looking to gain control and visibility of your printer fleets with MPS? With the Print DNA software suite, your Zebra MPS provider can remotely manage and optimize your printers, track and automate supplies replenishment and ensure security


Zebra Certified Supplies

Printing supplies provide a digital voice for assets across your supply chain. You rely on them to disseminate critical data throughout your organization. That’s why we design, produce and rigorously pretest our own line of labels, tags and receipt paper to ensure consistent, optimized performance in your Zebra printer. For industry-leading quality, service and thermal printing expertise, choose Zebra Certified Supplies.


Service When You Need it

Zebra OneCare™ offers unmatched technical support direct from Zebra, as well as comprehensive repair services. And Zebra’s Visibility Services provide real-time insights into printer operations to help optimize printer availability.


Healthcare Features 

• Healthcare preferred white color scheme • Healthcare-compliant power supply, IEC 60601-1 certified • Disinfectant-ready, easy-to-clean plastics with sealed button interface • UV-resistant housing supports UV cleaning protocols


Standard Features 

• Print methods: Thermal Transfer or Direct Thermal • ZPL and EPL programming languages • 4.3 in. full color touch LCD (resolution: 480 wide x 272 high) with 3-button user interface • 5 status icons interface • Ethernet, USB 2.0, USB Host • Printer setup mobile app for Android and iOS via BLE (Bluetooth Low Energy 5) connection* * BLE is intended for use with Zebra printer setup mobile app only • Real Time Clock (RTC) • Media dancer for excellent print quality • OpenACCESS™ for easy media loading • Dual-wall frame construction • ENERGY STAR® certified


Markets and Applications Healthcare 

• Prescription labels • Lab and specimen labels • Patient ID wristbands • Blood and IV bag labels • Patient record labels • Asset labels